Interesting concept! However, the sound effects are really obnoxious when you click the "combine" button. Also, I feel like the items should stay around a little longer, especially the ones that spawn from combining.
A quick game for AGBIC2016, based on Item Collect.
Click the chest to create items.
Left-click items to queue them up.
Right-click items to add them to your collection.
Click the left button to combine the shown items.
Try to find all the combinations and collect every item!